Exosome Counting Technology ExoCounter


Digital Exosome Counting Technology!
Easier, Faster and more Reliable way for biofluid samples
JVCKENWOOD Corporation applied Blu-ray technologies to exosome analysis. *Immuno-nanobeads labeling on optical disc
*Fabrication of disc with nanostructure (260nm)
*Optical detection & digital signal processing

Our technology realized high-speed, specific and size-selective counting of exosomes in biofluids.



This technology was developed through collaboration with Keio University School of Medicine, Tokyo Medical University,
and Tokyo Institute of Technology with the support by the Program of Development of Advanced Measurement
and Analysis Systems promoted by the Japan Science and Technology Agency (JST).

JVCKENWOOD Corporation and Sysmex Corporation have agreed to jointly develop diagnostic instruments
for the measurement of exosomes in March 2016.

>Detail (pdf : 152KB)

JVCKENWOOD Corporation, The National Cancer Center Japan, Sysmex Corporation and Daiich Sankyo Company Limited have agreed to collaborative research with the aim of raising the quality of cancer diagnosis and treatment.

>Detail (pdf : 91.4 KB)

The research article on digital exosome counting technology ExoCounter was published in an early online release of the US scientific journal Clinical Chemistry on Wednesday, July 18, 2018.


Nanobeads technology in ExoCounter

Immno-nanobeads labeling is one of the key technology in "ExoCounter". We asked Professor Hiroshi Handa (Tokyo Medical University | TMU · Department of Nanoparticle Translational Research) who developed nanobeads technology about "ExoCounter".

Professor Hiroshi Handa

Tokyo Medical University
TMU · Department of Nanoparticle Translational Research

My research group is working on developing nano-sized latex beads (SG beads) and magnetic nano-beads (FG beads) that can be used in bio-separators and next-generation biosensors, as well as enhancing their functionality in various applications. We have been undergoing collaborative research with not only academic partners but also industrial partners, seeking to move from basic research to developing practical applications. Our innovative nanobead technology has the ability to identify proteins that bind to pharmaceuticals, and contributes greatly to the field of chemical biology. The most impactful achievement of our research to date was the identification of cereblon, the protein that thalidomide binds to, demonstrating the mechanism of the harmful side effects of thalidomide. We provided evidence that cereblon is the cause of the teratogenesis that occurs by thalidomide. Based on this research, we discovered that thalidomide derivatives that bind to cereblon showed anticancer effects, paving the way for the strategic development of next-generation anticancer drugs.

ExoCounter, which was developed by JVCKENWOOD, uses FG beads as probes for bio-sensing, and detects individual exosomes with specific surface markers. In this system, the similarity of the sizes of exosomes, FG beads and nanostructures of the optical disc used for exosome immobilization ensures high detection precision. In addition, the magnetic material in FG beads enhances the detection signal, which enables high-sensitive detection. This is an outstanding example of the utilization of the properties of FG beads in a new field. Exosomes are currently an important subject of research for various diseases, such as cancer. Exosomes also have great potential for the development of new diagnostic and therapeutic technologies for personalized medicine. I strongly expect that ExoCounter will greatly contribute to the field of exosome research by enabling the accurate quantification of exosomes in various samples.


Short video presentation for our technology. Toward a liquid biopsy based on exosomes.


Kabe Y, et al. Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera.
Clinical chemistry,  (2018). 

Exhibition at ISEV2018

JVCKENWOOD Corporation and Sysmex Corporation jointly exhibited "ExoCounter" at ISEV2018. 
(ISEV2018: International Symposium for Extracellular Vesicles 2018 held in Barcelona)

"ExoCounter" is a trademark or registered trademark of JVCKENWOOD Corporation.